The potential Side Effects of
Posted on July 28, 2010
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The potential Side Effects of TCAs are allergic reactions, blood cell problems, blurred vision, dry mouth, weakness, fatigue, weight gain, constipation, difficulty with urination, sexual dysfunction, sweating, muscle twitches, rash, dizziness, tremors, ECG abnormalities, seizures, stroke, and Neuroleptic Malignant Syndrome (with amoxapine). The secondary amine TCAs (desipramine and nortriptyline) are generally better tolerated than tertiary amine TCAs.
The SSRIs are associated with nausea, anorexia, anxiety, agitation, insomnia, headache, dizziness, tremor somnolence, sweating, dry mouth, diarrhea, constipation, and sexual dysfunction as the general Side Effects. The sexual Side Effects of SSRIs often become the reason for its desired discontinuation.
The currently available SNRIs (desipramine, duloxetine, nefazodone, and venlafaxine) keep both serotonin and norepinephrine at the right level to alleviate depressive symptoms. The Side Effects associated with the use of nefazodone include dry mouth, constipation, and somnolence. Venlafaxine has significant anticholinergic effects (dry mouth, blurred vision, urinary hesitancy, and constipation) and induces sedation. Other Side Effects observed with its use are hypertension, agitation, tremor, sweating, headache, nausea and sleep disturbances. It has potential withdrawal effects.
The drug bupropion (Wellbutrin, Wellbutrin SR) is contraindicated in patients with seizure disorder or a history of anorexia nervosa or bulimia.
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